解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Nipah virus (NiV) causes severe encephalitis in humans, with high mortality. NiV nonstructural C protein (NiV-C) is essential for its pathogenicity, but its functions are unclear. In this study, we focused on NiV-C trafficking in cells and found that it localizes predominantly in the cytoplasm but partly in the nucleu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.07.013
更新日期:2016-10-01 00:00:00
abstract::The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the redu...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2016.07.004
更新日期:2016-10-01 00:00:00
abstract::West Nile virus (WNV) is a mosquito-borne flavivirus that causes febrile illness, encephalitis, and occasionally death in humans. The envelope protein is the main component of the WNV virion surface, and domain III of the envelope protein (EIII) is both a putative receptor binding domain and a target of highly specifi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.05.024
更新日期:2016-09-01 00:00:00
abstract::Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study, we successfully expressed FcaPV2 E6 and E7 putative oncogenes in feline epithelial cells and demonstrated that FcaPV2 E6 binds to p53...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.05.017
更新日期:2016-09-01 00:00:00
abstract::West Nile virus (WNV) is a flavivirus that swept rapidly across North America in 1999, declined in prevalence, and then resurged in 2012. To date, no vaccine is available to prevent infection in the human population. Herpes simplex virus (HSV) replication-defective vaccine vectors induce a durable immunity characteriz...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.06.006
更新日期:2016-09-01 00:00:00
abstract::The influenza PA-X protein is translated from the PA open reading frame from frameshifting and suppresses cellular gene expression due to its ribonuclease activity. We further defined the functional roles of PA-X by comparing PA-X proteins from two related viruses - equine influenza (EIV) and canine influenza (CIV) H3...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.06.001
更新日期:2016-09-01 00:00:00
abstract::To be incorporated into progeny virions, the viral genome must be transported to the inner leaflet of the plasma membrane (PM) and accumulate there. Some viruses utilize lipid components to assemble at the PM. For example, simian virus 40 (SV40) targets the ganglioside GM1 and human immunodeficiency virus type 1 (HIV-...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.05.018
更新日期:2016-09-01 00:00:00
abstract::We report the discovery of Nylanderia fulva virus 1 (NfV-1), the first virus identified and characterized from the ant, Nylanderia fulva. The NfV-1 genome (GenBank accession KX024775) is 10,881 nucleotides in length, encoding one large open reading frame (ORF). Helicase, protease, RNA-dependent RNA polymerase, and jel...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.06.014
更新日期:2016-09-01 00:00:00
abstract::Geminiviruses constitute one of the largest groups of plant viruses, having characteristic twinned geminate particles encapsidating small circular single-stranded DNA molecules. Geminiviral promoters are generally located within the intergenic region, although promoters have also been detected within the genes. Simila...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2016.04.033
更新日期:2016-08-01 00:00:00
abstract::Human schlafen11 is a novel restriction factor for HIV-1 based on bias regarding relative synonymous codon usage (RSCU). Here, we report the cloning of equine schlafen11 (eSLFN11) and the characteristics of its role in restricting the production of equine infectious anemia virus (EIAV), a retrovirus similar to HIV-1. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.04.024
更新日期:2016-08-01 00:00:00
abstract::In 2014-2015, the U.S. experienced an unprecedented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus, initially affecting mainly wild birds and few backyard and commercial poultry premises. To better model the outbreak, the pathogenesis and transmission dynamics of representative Eu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.04.019
更新日期:2016-07-01 00:00:00
abstract::Here, we evaluated the role of two host proteins, a Bromo domain containing RNA binding protein (BRP1) and Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), in the replication of Cucumber mosaic virus (CMV). LC-MS/MS analysis of host/viral proteins pull down against BRP1 from CMV-infected plants co-infiltrated with BR...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.04.001
更新日期:2016-07-01 00:00:00
abstract::Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, has caused significant damage to the Asian and American pork industries. Coronavirus 3C-like protease (3CL(pro)), which is involved in the processing of viral polyproteins for viral replication, is an appealing antiviral drug target. Here,...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.04.018
更新日期:2016-07-01 00:00:00
abstract::Replication and transmission of avian influenza virus in humans poses a pandemic threat. The molecular determinants that facilitate this process are not well understood. We used DBA/2 mice to identify viral factors that mediate the difference in pathogenesis between a virulent (H7N3) and a non-virulent (H7N9) avian in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.04.013
更新日期:2016-07-01 00:00:00
abstract::The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isolate A/Hamburg/04/2009 in A549 human lung epithelial cells. After...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.02.002
更新日期:2016-05-01 00:00:00
abstract::Due to the worldwide prevalence of antibiotic resistant strains, phages therapy has been revitalized recently. In this study, an Enterococcus faecium phage named IME-EFm5 was isolated from hospital sewage. Whole genomic sequence analysis demonstrated that IME-EFm5 belong to the Siphoviridae family, and has a double-st...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.02.006
更新日期:2016-05-01 00:00:00
abstract::Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.02.022
更新日期:2016-05-01 00:00:00
abstract::Circoviruses are relatively novel pathogens with increased importance in canids. In this study, we first screened the presence of dog circovirus (DogCV) by molecular methods from a total number of 389 internal organ samples originating from 277 individuals of domestic dogs and wild animals including wolves, foxes and ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.01.007
更新日期:2016-03-01 00:00:00
abstract::Enveloped virus entry occurs when viral and cellular membranes fuse releasing particle contents into the target cell. Human immunodeficiency virus (HIV) entry occurs by cell-free virus or virus transferred between infected and uninfected cells through structures called virological synapses. We developed a high-through...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.10.013
更新日期:2016-03-01 00:00:00
abstract::Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in cont...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.12.018
更新日期:2016-03-01 00:00:00
abstract::Chikungunya virus (CHIKV) represents a pandemic threat with no approved vaccine available. Recently, we described a novel vaccination strategy based on iDNA® infectious clone designed to launch a live-attenuated CHIKV vaccine from plasmid DNA in vitro or in vivo. As a proof of concept, we prepared iDNA plasmid pCHIKV-...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2016.01.009
更新日期:2016-03-01 00:00:00
abstract::Human cytomegalovirus (HCMV) was recently shown to encode a large number of spliced mRNAs. While the nuclear export of unspliced viral transcripts has been extensively studied, the role of host mRNA export factors in HCMV mRNA trafficking remains poorly defined. We found that the eIF4AIII RNA helicase, a component of ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.12.009
更新日期:2016-02-01 00:00:00
abstract::Feline calicivirus depends on host-cell proteins for its replication. We previously showed that knockdown of nucleolin (NCL), a phosphoprotein involved in ribosome biogenesis, resulted in the reduction of FCV protein synthesis and virus yield. Here, we found that NCL may not be involved in FCV binding and entry into c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.12.001
更新日期:2016-02-01 00:00:00
abstract::Significant economic losses in the poultry industries have resulted from H9N2 low pathogenic avian influenza virus infections across North Africa, the Middle East and Asia. The present study investigated the evolutionary dynamics of H9N2 viruses circulating in Korea from 1996 to 2012. Our analysis of viral population ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.11.023
更新日期:2016-01-15 00:00:00
abstract::HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervic...
journal_title:Virology
pub_type: 杂志文章,meta分析
doi:10.1016/j.virol.2015.11.016
更新日期:2016-01-15 00:00:00
abstract::Direct attenuation of West Nile (WN) virus strain NY99 for the purpose of vaccine development is not feasible due to its high virulence and pathogenicity. Instead, we created highly attenuated chimeric virus W1806 with the serological identity of NY99. To further attenuate W1806, we investigated effects of mutations f...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.10.015
更新日期:2016-01-01 00:00:00
abstract::Cucumber mosaic virus (CMV) is a damaging pathogen of over 200 mono- and dicotyledonous crop species worldwide. It has the broadest known host range of any virus, but the timescale of its evolution is unknown. To investigate the evolutionary history of this virus, we obtained the genomic sequences of 40 CMV isolates f...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.09.024
更新日期:2016-01-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various step...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.08.026
更新日期:2015-12-01 00:00:00
abstract::Essential host cofactors in retrovirus replication bind cis-acting sequences in the 5'untranslated region (UTR). Although host RBPs are crucial to all aspects of virus biology, elucidating their roles in replication remains a challenge to the field. Here RNA affinity-coupled-proteomics generated a comprehensive, unbia...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.06.001
更新日期:2015-12-01 00:00:00
abstract::We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSS gene...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.09.003
更新日期:2015-12-01 00:00:00
abstract::While the 2009 pandemic H1N1 virus has become established in the human population as a seasonal influenza virus, continued adaptation may alter viral virulence. Here, we passaged a 2009 pandemic H1N1 virus (A/Changchun/01/2009) in mice. Serial passage in mice generated viral variants with increased virulence. Adapted ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.09.014
更新日期:2015-12-01 00:00:00
abstract::Understanding the mechanism of HIV-1 latency is crucial to the viral reservoir eradication. Human cellular miRNAs can modulate HIV-1 expression by targeting of viral RNAs or host gene transcripts. To identify miRNAs modulating HIV-1 latency, we determined the miRNA expression profiles of HIV-1 latently infected and pr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.09.016
更新日期:2015-12-01 00:00:00
abstract::HIV-1 envelope glycoproteins (Env) and Env-based immunogens usually do not interact efficiently with the inferred germline precursors of known broadly neutralizing antibodies (bNAbs). This deficiency may be one reason why Env and Env-based immunogens are not efficient at inducing bNAbs. We evaluated the binding of 15 ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.08.002
更新日期:2015-12-01 00:00:00
abstract::To identify ranavirus virulence genes, we engineered Frog Virus 3 (FV3) knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD) protein (Δ64R-FV3) and a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3). Compared to wild type (WT) FV3, infection of Xenopus tadpo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.07.011
更新日期:2015-11-01 00:00:00
abstract::Condylomata acuminata is caused by human papillomavirus (HPV). PCR with consensus primers will typically detect HPV in >96% of condylomata. Metagenomic sequencing has found that some "HPV-negative" condylomata do indeed contain HPV. We wished to perform a renewed evaluation of the "HPV-negative" condylomata using deep...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.07.023
更新日期:2015-11-01 00:00:00
abstract::Respiratory syncytial virus is a major cause of bronchiolitis in infants and pneumonia virus of mice (PVM) causes similar disease in mice. The impact of PVM infection in BALB/c and C57BL/6 neonates, and upon re-infection as elderly mice, was compared. As previously shown for adult mice, PVM caused more disease in BALB...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.07.019
更新日期:2015-11-01 00:00:00
abstract::Expression of adenosine deaminase acting on RNA1 (ADAR1) is driven by alternative promoters. Promoter PA, activated by interferon (IFN), produces transcripts that encode the inducible p150 ADAR1 protein, whereas PB specifies the constitutively expressed p110 protein. We show using Stat1(-/-), Stat2(-/-) and IRF9(-/-) ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.08.001
更新日期:2015-11-01 00:00:00
abstract::Human norovirus is a dominant cause of acute gastroenteritis around the world. Several norovirus disinfectants label citric acid as an active ingredient. In this study, we showed that norovirus virus-like particles (VLPs) treated with citrate buffer caused the particles to alter their morphology, including increased d...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.07.009
更新日期:2015-11-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema accumulation and death. IL-1β driven proinflammation is associated with those pathological signatures,...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.08.010
更新日期:2015-11-01 00:00:00
abstract::Given dengue virus (DENV) genome austerity, it uses cellular molecules and structures for virion entry, translation and replication of the genome. NS1 is a multifunctional protein key to viral replication and pathogenesis. Identification of cellular proteins that interact with NS1 may help in further understanding the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.05.017
更新日期:2015-10-01 00:00:00